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何侃

来源:  发布时间:2017-2-15 访问次数:1176


  • 何侃

    单位职务:安徽大学,生命科学学院,生物统计系主任

    研究方向:统计基因组学与生物信息学

    电子邮箱:hekan_803@163.com

    办公室电话:0551-63861819


    教育经历(按时间倒排序):

    2009/9 - 2012/6,上海交通大学,博士

    2007/9 - 2009/6,上海交通大学,硕士

    2002/9 - 2006/6,东北农业大学,学士


    工作经历(科研与学术工作经历,按时间倒序排序):

    2013/12 - 至今,安徽大学,生命科学学院,副教授

    2012/08- 2013/08,香港浸会大学,理学院生物系,博士后


    主持或参加科研项目及人才计划项目情况(按时间倒序排序):

    1、安徽省自然科学基金青年项目,2015/07-2017/06,8万元,在研,主持。

    2、安徽大学高层次人才引进计划项目,2014/01-2018/12,40万元,在研,主持。

    3、国家自然科学基金面上项目,2015/07-2018/06,66万元,在研,参与。

    4、香港CRF(CollaborativeResearch Fund)项目,2012/07-2016/06,400万港元,在研,参与。

    5、国家自然科学基金面上项目,2009/07-2012/06,36万元,结题,参与。


    发表学术论文(黑体字部分为本人):

    [1] Kan He, Wenwen Lv, Dongni Zheng, Fei Cheng, Tao Zhou, Shoudong Ye,Qian Ban, Qilong Ying, Bei Huang, Lei Chen, Guohua Wu and Dahai Liu:Thestromal genome heterogeneity between breast and prostate tumors revealed by acomparative transcriptomic analysis. Oncotarget 2015, 6(11):8687-97. 

    [2] Shao J*, He K*, Wang H*, Ho WS, Ren X, An X, Wong MK, Yan B, Xie D,Stamatoyannopoulos J, Zhao Z:CollaborativeRegulation of Development butIndependent Control of Metabolismby Two Epidermis Specific Transcription Factors in C. elegans. Journalof Biological Chemistry 2013, 288:33411-33426. (* these authorscontribute equally to the manuscript). 

    [3] He K, Zhou T, Shao J, Ren X, Zhao Z, Liu D: Dynamic regulation ofgeneticpathways and targets during agingin Caenorhabditis elegans. Aging-US, 2014, 6(3):215-230.

    [4] He K, Shao J, Zhao Z, Liu D: The comprehensive transcriptionalanalysis inCaenorhabditis elegans byintegrating ChIP-seq and gene expression data. GeneticsResearch. 2014, 96:e005. 

    [5] He K, Xiao W, Lv W: Comprehensive identification of essentialpathways andtranscription factors related toepilepsy by gene set enrichment analysis on microarraydatasets. International Journal ofMolecular Medicine. 2014, 34(3):715-24.

    [6] He K, Wang Q, Wang Z, Pan Y: Association study between genepolymorphismsin PPAR signaling pathway andporcine meat quality traits. Mammalian Genome2013, 24(7-8): 322-331. 

    [7] He K, Wang Z, Wang Q, Pan Y: A meta-analysis study of geneexpression datasets in mouse liver under PPARα knockout. Genetics Research 2013,95(2-3):78-88.

    [8] He K, ZL Chen, YF Ma and YC Pan: Identification of high copperresponsivetarget pathways in Atp7b knockoutmouse liver by GSEA on microarray datasets.Mammalian Genome 2011,22(11-12):703-713.

    [9] He K, QS Wang, YM Yang, MH Wang, YC Pan: A Comparative Study ofMouseHepatic and Intestinal GeneExpression Profiles under PPARalpha Knockout by GeneSet Enrichment Analysis. PPARResearch 2011, 2011: 629728. 

    [10] He K, F Yang, MH Wang, QS Wang, YC Pan and YF Ma: Identification ofpigreproductive QTL genes based ongene set enrichment analysis of mouse microarraydataset. African Journal of AgriculturalResearch 2011, Vol. 6(13), pp3196-3202.

    [11] He K, HB Zhao, QS Wang, YC Pan: A comparative genome analysis ofgeneexpression reveals differentregulatory mechanisms between mouse and humanembryo pre-implantationdevelopment. Reproductive Biology and Endocrinology2010, 8:41.

    [12] He K, HB Zhao, CY Bai, QS Wang, YC Pan: Study on regulatorymechanism ofbovine early embryos developmentbased on the analysis of gene expression data. YiChuan 2010, 32: 726-731.

    [13] Zhen Wang, Kan He, Qishan Wang, Yumei Yang and YuchunPan: Theprediction of the porcinepre-microRNAs in genome-wide based on support vectormachine (SVM) and homologysearching. BMC Genomics 2012, 13:729.

    [14] Xie X X, He K, Zhang A L, et al. Comparative study of the promotion ofporcinefetal fibroblast proliferation byoverexpression of two transcriptional variants ofSIRT6. Chinese Science Bulletin2013, 58(10):1174.

    [15] YANG Fan, WANG QiongPing, WANGMingHui, HE Kan, PAN YuChun:Associations between genepolymorphisms in two crucial metabolic pathways andgrowth traits in pigs. ChineseScience Bulletin 2012, 21(8):2733-2740.

    [16] Fan Yang, Qiong-Ping Wang, Kan He, Ming-Hui Wang, Yu-Chun Pan:Association between genepolymorphisms of propanoate metabolism pathway andmeat quality as well as carcasstraits in pigs. Yi Chuan 2012, 34(7):872-878.

    [17] Zhao HB, QS Wang, CY Bai, K He and YC Pan: A cross-study genesetenrichment analysis identifiescritical pathways in endometriosis. ReproductiveBiology and Endocrinology 2009, 7:94. 

    [18] 何侃,蒋越,王起山,俞沛初,潘玉春: 基于芯片数据分析关于SREBP-lc调控脂肪代谢过程作用机理的研究. 黑龙江畜牧兽医(科技版) 2010, 7:1-4.

    [19] 何侃,赵洪波,潘玉春: 子宫内膜异位症芯片的元分析研究. 上海交通大学学报2009, 27(5): 506-512.


    专利与软件著作权:

    [1]. 王起山、潘玉春、张向喆、王明辉、陈强、何侃、王振,2011:畜禽基因组SNP 基因集富集分析系统(GWAS-KNOW),中国,授权号:2011SR055347。

    [2]. 王起山、潘玉春、张向喆、马育芳、陈强、何侃、杨玉梅,2011:基于基因组选择的基因集富集分析系统(GS4GSEA),中国,授权号:2011SR055344。

    [3]. 潘玉春,王起山,王明辉,赵洪波,张向喆,胡艳玲,何侃,2009:单体型标记辅助选种选配系统(简称:HAPMAS).软件著作权授权号:2009SR08213。

    [4]. 潘玉春,胡艳玲,王起山,赵洪波,张向喆,王明辉,何侃,2009:基因组多区域单体型联合分析软件( 简称:HAPGLM).软件著作权授权号:2009SR07478。

    [5]. 潘玉春,胡艳玲,王起山,赵洪波,张向喆,王明辉,何侃,2009:动态性状单体型联合分析软件( 简称:HAPGAMM). 软件著作权授权号:2009SR07479。