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田肖和

来源:  发布时间:2017-3-21 访问次数:3933

  •     名:田肖和

    箱:xiaohe.t@ahu.edu.cn

    称:副教授

    地址: 安徽大学理工C楼

    编码:230000

     

    教育背景:

    2013/11-2015/05 博士后 英国伦敦大学学院化学学院

    2010/06-2013/11英国谢菲尔德大学, 神经科学和药物运输专业,博士,生物医学学院

    2008/08-2010/05,英国谢菲尔德大学, 生物纳米技术专业,硕士,工程与材料学院

     

    科学域描述:

    1,中枢神统药物靶向系

    通过对血脑屏障的三维(3D)和体内建模,研究双氰基类化合物对血脑屏障(BBB,blood-brain-barrier)的穿透作用,并探索其分子机理。研究该类小分子在透过BBB后,对阿尔兹海默症的淀粉类沉淀的靶向及清除作用。

    2,小分子光探针对蛋白及亚细胞器的靶向。

    利用亚细胞器内微环境的不同以及蛋白质的构象,设计合成与其特异响应的小分子光探针,在分子水平下达到对亚细胞器生理环境及动态变化的检测。

    3,新型配位化合物在超分辨成像中的应用。

    与伦敦大学学院化学学院Giuseppe Battaglia教授合作,利用金属配合物在超分辨显微镜和液相电子透射显微镜下构建细胞骨架的超精细结构。

     

    研究

    国家自然科学青年基金(主持,21602003,2016)

    安徽省面上基金(主持,1708085MC68,2017)

    安徽省留学人员创业创新扶植计划(2017,重点)

     

     

     

     


    主要表文章:

     

      第一作者和共同第一作者:

    1)   1) Tian X*, Wang H, Zhang Q, Zhang M, Zhu Y, Chen Y, Wu J, Tian Y. Double labelling of intracellular mitochondria and nucleolus using thiophene pyridium salt with high quantum yield as biosensor and its application in stimulated emission depletion nanoscopy. Analytica Chimica Acta. 2018. 1008, 82-89 (IF= 4.950, JCR1, Top期刊)

    2)    2)Tian X*, Hussain S, Wang J, Zhang Q, Zhao M, Chen J, Zhang H, Zhou H, Chen Y, Tian Y. A series of water-soluble pyridinium derivatives with near infrared two-photon absorption for mitochondria targeting under stimulated emission depletion (STED) nanoscopy. Dyes and Pigments. 2017. 147, 90-98 (IF= 3.473, JCR1, Top期刊)

    3)    3)Tian X*, Zhu Y, Zhang Q, Zhang R, Wu J, Zhou H, Guan L, Battaglia G, Tian Y. Halides Tuning Subcellular-Targeting in Two-Photon Emissive Complexes via Different Uptake Mechanisms. Chemical  Communication. 2017; 53, 7941-7944. (IF= 6.319, JCR1, Top期刊)

    4)    4)Tian X*, Zhu Y, Zhang M, Luo L, Wu J, Zhou H, Guan L , Battaglia G, Tian Y. Localization Matters: A Nuclear Targeting Two-Photon Absorption Iridium Complex Induced Intracellular Immigration and Dual-damage in Photon Dynamic Therapy. Chemical  Communication. 2017; 53, 3303-06. (IF= 6.319, JCR1, back cover highlighted, Top期刊)

    5)    5)Tian X*, Zhu Y, Zhang M, Tan J, Zhang Q, Wang X, et al. Mild acidic-enhanced mitochondrial-targeting by a neutral thiophene based terpyridine molecule with large two-photon action cross-section. Dyes and Pigments. 2017;139:431-9.(IF= 3.473, JCR1, Top期刊)

    6)    6)Tian X*, Zhang Q, Zhang M, Uvdal K, Wang Q, Chen J, et al. Probe for simultaneous membrane and nucleus labeling in living cells and in vivo bioimaging using a two-photon absorption water-soluble Zn(ii) terpyridine complex with a reduced π-conjugation system. Chemical Science. 2017;8:142-9. (IF= 8.668, JCR1, Top期刊)

    7)    7)Tian X*, Brookes O, Battaglia G. Pericytes from Mesenchymal Stem Cells as a model for the blood-brain barrier. Scientific reports. 2017;7:39676. (IF=4.259, JCR2, Top期刊)

    8)    8)Tian X*, Wang H, Guan L, Zhang Q, Zhou H, Li C, et al. Light up Live Cell Nuclear Envelope in Real-Time Using a Two-Photon Absorption and AIE Chromophore. Journal of fluorescence. 2016;26:59-65. (IF=1.601, JCR4, Top期刊)

    9)    9)Tian X*, Nyberg S, Sharp PS, Madsen J, Daneshpour N, Armes SP, et al. LRP-1-mediated intracellular antibody delivery to the Central Nervous System. Scientific reports. 2015;5. (IF=4.259, JCR2, Top期刊)

    10) 10)Tian X*, Gill MR, Cantón I, Thomas JA, Battaglia G. Live cell luminescence imaging as a function of delivery mechanism. ChemBioChem. 2011;12:548-51. (IF=2.850, JCR2, Top期刊)

    11) 11)Jiang J, Tian X*, Xu C, Wang S, Feng Y, Yu H, Zhu M, Meng X. A two-photon fluorescent probe for monitoring autophagy by ultrasensitive detection of the change in lysosomal polarity. Chemical Communication. 2017; 53, 3645-3648. (IF= 6.319, JCR1, Top期刊)

    12)  12)Li D, Tian X*, Wang A, Guan L, Zheng J, Li F, et al. Nucleic acid-selective light-up fluorescent biosensors for ratiometric two-photon imaging of the viscosity of live cells and tissues. Chemical Science. 2016;7:2257-63. (IF= 8.668, JCR1, Top期刊)

    13)  13)Wang H, Tian X*, Guan L, Zhang Q, Zhang S, Zhou H, et al. Targeting mitochondrial DNA with a two-photon active Ru (ii) phenanthroline derivative. Journal of Materials Chemistry B. 2016;4:2895-902. (IF= 4.872, JCR1, Top期刊)

    14)  14)Zhang Q, Tian X*, Hu G, Shi P, Wu J, Li S, et al. Dual-Functional Analogous cis-Platinum Complex with High Antitumor Activities and Two-Photon Bioimaging. Biochemistry. 2015;54:2177-80. (IF=2.876, JCR3, Top期刊)

    15)  15)Zhang Q, Tian X*, Hu Z, Brommesson C, Wu J, Zhou H, et al. Nonlinear optical response and two-photon biological applications of a new family of imidazole-pyrimidine derivatives. Dyes and Pigments. 2016;126:286-95. (IF= 3.473, JCR1, Top期刊)

    16)  16)Zhang Q, Tian X*, Wang H, Hu Z, Wu J, Zhou H, et al. NIR-region two-photon fluorescent probes for Fe3+/Cu2+ ions based on pyrimidine derivatives with different flexible chain. Sensors and Actuators B: Chemical. 2016;222:574-8. (IF= 5.401, JCR1, Top期刊)

     

    作者:

    17) 17)Zhao M, Liu D, Zhou L, Wu B, Tian X♯ et al. Two water-soluble two-photon fluorescence probes for ratiometric imaging endogenous SO2 derivatives in mitochondria. Sensors and Actuators B: Chemical. 2017. (IF= 5.401, JCR1, Top期刊)

    18) 18)Du W, Wang H, Zhu Y, Tian X♯ et al. Highly Hydrophilic, Two-photon Fluorescent Terpyridine Derivatives Containing Quaternary Ammonium for Specific Recognizing Ribosome RNA in Living Cells. ACS Applied Materials & Interfaces. 2017, 9, 31424−31432  (IF= 7.504, JCR1, Top期刊)

    19)  19)Feng Y, Li S,  Li D, Wang Q, Ning P, Chen M, Tian X♯, Wang X. Rational design of a diaminomaleonitrile-based mitochondria − targeted two-photon fluorescent probe for hypochlorite in vivo: solvent-independent and high selectivity over Cu2+. Sensors and Actuators B: Chemical. 2017; (IF= 5.401, JCR1, Top期刊)

    20) 20)Su J, Zhang J, Tian X♯ et al. A series of multifunctional coordination polymers based on terpyridine and zinc halide: second harmonic generation and two-photon absorption properties and intracellular imaging. Journal of Materials Chemistry B. 2017; 5, 5458-5463  (IF= 4.872, JCR1, Top期刊)

    21) 21)Hu L, Wang H, Fang B, Hu Z, Zhang Q, Tian X♯, Zhou H, et al. A reversible two-photon fluorescence probe for Cu(II) based on Schiff-base in HEPES buffer and in vivo imaging. Sensors and Actuators B: Chemical. 2017; (IF= 5.401, JCR1, Top期刊)

    22) 22)Chen S, Zhao M, Su J, Zhang Q, Tian X♯, Li S, et al. Two novel two-photon e, , xcited fluorescent pH probes based on the A-π-D-π-A system for intracellular pH mapping. Dyes and Pigments. 2017;136:807-16. (IF= 3.473, JCR1, Top期刊)

    23) 23)Hu L, Wang H, Xu X, Zhang M, Tian X♯, Wu J, et al. A small-molecule with large two-photon action cross-section serves as the membrane-permeable probe for live cells imaging and bacteria viability. Sensors and Actuators B: Chemical. 2017;241:1082-9. (IF= 5.401, JCR1, Top期刊)

    24) Li W, Tian X♯, Huang B, Li H, Zhao X, Gao S, et al. Triphenylamine-based Schiff bases as the High sensitive Al3+ or Zn2+ fluorescence turn-on probe: Mechanism and application in vitro and in vivo. Biosensors and Bioelectronics. 2016;77:530-6. (IF= 7.476, JCR1, Top期刊)

    25)  Wang H, Tian X♯, Du W, Zhang Q, Guan L, Wang A, et al. A two-photon fluorescent RNA probe screened from a series of oxime-functionalized 2, 2′: 6′, 2′′-terpyridine ZnX2 (X= Cl, Br, I) complexes. Journal of Materials Chemistry B. 2016;4:4818-25. (IF= 4.872, front cover highlighted , JCR1, Top期刊)

    26)  Zhao M, Zhu Y, Su J, Geng Q, Tian X♯, Zhang J, et al. A water-soluble two-photon fluorescence chemosensor for ratiometric imaging of mitochondrial viscosity in living cells. Journal of Materials Chemistry B. 2016;4:5907-12. (IF= 4.872, JCR1, Top期刊)

    27)  Li D, Shi Y, Tian X♯, Wang M, Huang B, Li F, et al. Fluorescent probes with dual-mode for rapid detection of SO 2 derivatives in living cells: Ratiometric and two-photon fluorescent sensors. Sensors and Actuators B: Chemical. 2016;233:1-6. (IF= 5.401, JCR1, Top期刊)

    28)  H Wang, L Hu, W Du, Tian X♯, Q Zhang, et al.Two-Photon Active Organotin (IV) Carboxylate Complexes for Visualization of Anticancer Action. ACS Biomaterials Science & Engineering. 2017, 3, 5, 836–842