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陈彦

来源:生命科学学院  发布时间:2019-02-22 访问次数:12659

  • 姓名:陈彦

    邮箱:chenyan600@163.com;

    职称:教授

    电话:0551-63861751

    地址:合肥市经开区九龙路111号(230601) 安徽大学磬苑校区 理工C楼501-506室

    个人简介:

      安徽大学生命科学学院教授,博士生导师。先后于安徽农业大学、安徽大学和合肥工业大学获农学学士、理学硕士和工学博士学位。1991年安徽大学研究生毕业留校任教,历任讲师、副教授、教授、生物实验教学中心主任、生命科学学院副院长。现为生态工程与生物技术安徽省重点实验室主任,安徽省学术和技术带头人,安徽省生物化学与分子生物学学会副理事长,安徽省食品科学技术学会副理事长。

      作为主持人先后承担国家自然科学基金项目、省科技重大专项、省科技攻关计划项目、省高校科研平台创新团队建设项目等研究课题。2010年来以第一/通讯作者在国际学术期刊发表SCI论文40余篇,获安徽省科学技术三等奖1项(第一完成人);获国家授权发明专利13项(第一发明人,其中7项已转让)。

    主要研究方向:

     1、真菌活性多糖的结构与功能;

     2、天然活性产物的抗肿瘤/抗衰老作用机制;

     3、功能食品/保健品的开发与研究。

    近年发表主要论文(*通讯作者)

    1. Wen-Na Zhang, Ri-Na Su, Li-Li Gong, Wei-Wei Yang, Juan Chen, Rui Yang, Ya Wang, Wen-Juan Pan, Yong-Ming Lu, Yan Chen*. Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. Seeds, Carbohydrate Polymers. 2019,209 :363–371

    2. Wei-Wei Yang, Li-MingWang, Li-Li Gong, Yong-Ming Lu, Wen-Juan Pan, Ya Wang, Wen-Na Zhang*, Yan Chen*. Structural characterization and antioxidant activities of a novel polysaccharide fraction from the fruiting bodies of Craterellus cornucopioides, International Journal of Biological Macromolecules. 2018,117:473–482

    3. Wan Li, Zheng-Nan Cai, Shomaila Mehmood, YaWang,Wen-Juan Pan, Wen-Na Zhang, Yong-Ming Lu*,Yan Chen*. Polysaccharide isolated from Sarcodon aspratus induces RAW264.7 activity via TLR4-mediated NF-κB and MAPK signaling pathways, International Journal of Biological Macromolecules. 2018,120:1039–1047

    4. Zheng-Nan Cai, Wan Li, Shomaila Mehmood, Wen-Juan Pan, Ya Wang, Fan-Ju Meng, Xiao-Fang Wang, Yong-Ming Lu*, Yan Chen*.  Structural characterization, in vitro and in vivo antioxidant activities of aheteropolysaccharide from the fruiting bodies of Morchella esculenta, Carbohydrate Polymers. 2018,195:29-38

    5. Mingzhu Zhang, Rina Su, Qiong Zhang, Lei Hu, Xiaohe Tian, Yan Chen*. Hongping Zhou, Jieying Wu, Yupeng Tian*,Ultra-bright intercellular lipids pseudo di-BODIPY probe with lowmolecular weight, high quantum yield and large two-photon actioncross-sections, Sensors and Actuators B: Chemical, Sensors and Actuators B. 2018,261 :161-168

    6. Sajid Hussain, Wei Du,Mingzhu Zhang, Bin Fang, Guocui Zhang, Rina Su,Keqian Nan, Qiong Zhang, Xiaohe Tian*, Yupeng Tian* and Yan Chen*. A series of two-photon absorption pyridinium sulfonate inner salts targeting endoplasmic reticulum (ER), inducing cellular stress and mitochondria-mediated apoptosis in cancer cells Journal of Materials Chemistry B. 2018,6, 1943-1950

    7. Wen-Juan Pan, Qiu-Ying Ding, Ya Wang, Dan-Dan Wang, Yong-Ming Lu, Wei-Wei Yang, Zheng-Nan Cai, Xiao-Du Cheng, Wen-Na Zhang, Yan Chen*.A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense .protects against oxidative stress-induced premature senescence in cells and mice , Journal of Functional Foods. 2018,42:159-170

    8. Mingzhu Zhang, Xiaohe Tian, Ya Wang, Dandan Wang, Wan Li , Lei Chen, Wenjun Pan, Shomaila Mehmood,Yan Chen*. Immunomodulating activity of the polysaccharide TLH-3 from Tricholomalobayense in RAW264.7 macrophages, International Journal of Biological Macromolecules. 2018,107:2679-2685

    9. Wan Li, Zheng-Nan Cai, Shomaila Mehmood, Ya Wang,Wen-Juan Pan, Wen-Na Zhang,Yong-Ming Lu*,Yan Chen*,Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K/AKT/Nrf2/HO-1 pathway, International Journal of Biological Macromolecules, 2018,120 :865–875

    10. Dan-Dan Wang, Qing-Xi Wu, Wen-Juan Pan, Sajid Hussain, Shomaila Mehmood and Yan Chen*, A novel polysaccharide from the Sarcodon aspratus triggers apoptosis in Hela cells via induction of mitochondrial dysfunction, Food & Nutrition Research, 2018,62:1285

    11. Qing-Xi Wu*, Jun-Qi Yu, Wei Ying, Ting Su, Xiao-Du Cheng, Jin Zhao and Yan Chen*. Cultivation of the Wild Ganoderma gibbosum Mycelia via Submerged Liquid Fermentation for Inter/Extra-Cellular Polysaccharides,International Journal of Agriculture and  Biology.2018,20(5): 1218-1224

    12. Qing-Xi Wu, Dan-Dan Wang,Ting Su, Xiao-Du Cheng, Xin Xu .Yan Chen*. Self-assembly of polyelectrolyte complexes microcapsules with natural polysaccharides for sustained drug release, Cellulose. 2017, 24:4949-4962

    13. Xiaohe Tian , Sajid Hussain, Hui Wang , Qiong Zhang , Meng Zhao ,Junyang Chen , Hui Zhang , Hongping Zhou , Yan Chen*, Yupeng Tian*.A series of water-soluble pyridinium derivatives with two-photon absorption in the near infrared region for mitochondria targeting under stimulated emission depletion (STED) nanoscopy, Dyes and Pigments. 2017, 147: 90-98

    14. Yan Chen*, Xue-Hui Li, Li-Yuan Zhou, Wan Li, Liu Liu, Dan-Dan Wang, Wen-Na Zhang,Sajid Hussain, Xiao-He Tian, Yong-Ming Lu*. Structural elucidation of three antioxidative polysaccharides fromTricholoma lobayense, Carbohydrate Polymers. 2017,157 : 484–492

    15. Liming Wang & Yan Chen*. Efficient Biotransformation of Astragaloside IV to Cycloastragenol by Bacillus sp. LG-502, Applied Biochemistry and Biotechnology. 2017,183(4):1488-1502

    16. Yong-Ming Lu,Qiao-Yue Yang,Li-Ming Wang,Ming-Zhu Zhang,Wen-Qiang Guo,Zheng-Nan Cai,Dan-Dan Wang,Wei-Wei Yang,Yan Chen*. Enhanced Activity of Immobilized Horseradish Peroxidase by Carbon Nanospheres for Phenols Removal, CLEAN-Soil Air Water. 2017, 45(2):1600077

    17. Zhenyu Yue, Hai-Tao Li, Yabing Yang, Sajid Hussain, Chun-Hou Zheng, Junfeng Xia*, Yan Chen*.Identification of breast cancer candidate genes using gene co-expression and protein-protein interaction information, Oncotarget. 2016,7(24) : 36092 -36100

    18. Qiuying Ding, Dan Yang, Wenna Zhang, Yongming Lu, Mingzhu Zhang, Liming Wang,Xuehui Li, Liyuan Zhou, Qingxi Wu, Wenjuan Pan, Yan Chen*. Antioxidant and anti-aging activities of the polysaccharide TLH-3from Tricholoma lobayense, International Journal of Biological Macromolecules. 2016, 85: 133-140

    19. Xuehui Li, Yongming Lu, Wenna Zhang, Shixiong Yuan, Liyuan Zhou, Liming Wang,Qiuying Ding, Dandan Wang, Weiwei Yang, Zhengnan Cai, Yan Chen*. Antioxidant capacity and cytotoxicity of sulfated polysaccharideTLH-3 from Tricholoma lobayense, International Journal of Biological Macromolecules. 2016, 82: 913-919.

    20. Wenna Zhang, Yongming Lu, Yaping Zhang, Qiuying Ding, Sajid Hussain, Qingxi Wu, Wenjuan Pan & Yan Chen*. Antioxidant and antitumour activities of exopolysaccharide from liquid-cultured Grifola frondosa by chemical modification. International Journal of Food Science and Technology. 2016,51(4) : 1055-1061

    21. Liu Liu, Yongming Lu, Xuehui Li, Liyuan Zhou, Dan Yang, Liming Wang, Yan Chen*. A novel process for isolation and purification of the bioactivepolysaccharide TLH-3from Tricholoma lobayense,Process Biochemistry.2015,50 :1146–1151

    22. Zhenyu Yue,Wenna Zhang, Yongming Lu,Qiaoyue Yang, Qiuying Ding, Junfeng Xia*and Yan Chen*. Prediction of cancer cell sensitivity to natural products based on genomic and chemical properties. PeerJ, 2015,3:e1425

    23. Yong-Ming Lu , Jian Pan,Wen-Na Zhang , Ai-Ling Hui , Wen-Qiang Guo, Li Huang, Qin-Jun Zhu , Yan Chen*. Synthesis, in silico and in vivo blood brain barrier permeability of ginkgolide B cinnamate, Fitoterapia. 2015,106 :110-114

    24. Yan Chen, Meili Hu*, Cui Wang, Yuling Yang, Jianhua Chen, Jingna Ding, Wenqiang Guo. Characterization and in vitro antitumor activity of polysaccharides from the mycelium of Sarcodon aspratus ,International Journal of Biological Macromolecules. 2013,52:52-58

    25. Peilu Duan, Tianlong Zhai, Cunji Xu, Jingna Ding & Yan Chen*. A simple and effective method for detecting toxicity of chromium trioxide on Vicia faba, European Food Research and Technology. 2013, 236:517-521

    26. Meili Hu, Yan Chen*, Cui Wang, Huali Cui, Peilu Duan, Tianlong Zhai, Yuling Yang & Shaofei Li. Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculent, Biotechnology Letters. 2013, 35:1-10

    授权发明专利(第一发明人)

    1. 一种兼具抗肿瘤作用的抗氧化剂及其制备方法,2018.12.28,中国发明专利ZL201610573418.0

    2. 一种高纯度萝卜硫素的制备方法,2017.06.20,中国发明专利ZL201410632932.8

    3. 一种以固定化酶去除工业废水中扑息热痛的方法,2017.06.13,中国发明专利ZL201510455090.8

    4. 一种金钗石斛多糖和总碱的提取分离方法,2017.02.08,中国发明专利ZL201410628418.7

    5. 一种以金福菇为原料提取分离金福菇多糖TLH-3的方法,2016.02.17,中国发明专利ZL201410318373.3

    6. 一种植物与微生物多糖的纯物理制备方法,2015.12.09,中国发明专利ZL201210471031.6(已转让)

    7. 一种促进醒酒和防醉的中药提取物复配制剂及其制备方法和应用,2015.10.21,中国发明专利ZL201210319130.2(已转让)

    8. 一种石斛饮料的制备方法,2015.08.05,中国发明专利ZL201310462318.7 (已转让)

    9. 一种银杏鲜汁原液的制备方法,2015.08.05,中国发明专利ZL201310462280.3(已转让)

    10. 一种天然抗氧化剂金福菇多糖 的制备方法,2014.02.12,中国发明专利ZL201210014537.4(已转让)

    11. 一种以棕榈油为基油的低反式脂肪酸冰淇淋专用油脂的制备方法,2013.10.16,中国发明专利ZL201210232641.0

    12. 一种同步浸提、分项制取丹皮中各活性成分的制备方法,2011.06.22,中国发明专利ZL200810195489.7(已转让)

    13. 一种食用植物油中残留DNA的提取方法,2011.03.30,中国发明专利ZL200710025573.X(已转让)