您现在的位置:首页  师资队伍

何超

来源:生命科学学院  发布时间:2019-02-19 访问次数:6662

  • 姓名:何超

    邮箱:chaohe@ahu.edu.cn

    联系电话:0551-63861928

    地址:安徽省合肥市经开区九龙路111号安徽大学生命科学学院,

    理工C楼209室

    邮政编码:230601

    学习及工作经历:

    2013/06 -至今,安徽大学,生命科学学院,副教授

    2013/06 – 2018/12,安徽大学,生命科学学院,讲师;

    2006/09 - 2012/06,中国科学技术大学,生命科学学院

    2002/06 - 2006/06,东南大学,吴健雄学院;

    主要研究方向:

    1. 酶催化与调节的结构基础

    2. 基因表达调控重要蛋白质的结构与功能

    主持主要研究项目:

    1. 国家自然科学青年基金项目“Spp1蛋白质作为接头分子联系组蛋白修饰与减数分裂重组起始的三维结构基础”,31400643,2015/01-2017/12;

    2. 安徽省自然科学基金青年项目“小鼠苏氨酸脱氢酶催化与调节的分子机制”,1408085QC49,2015/01-2016/12;

    3. 安徽省高等学校省级自然科学研究重点项目“铜绿假单胞菌脂多糖合成相关糖基转移酶

    4. MigA的结构和功能研究”,KJ2018A0002,2019.01-2020.12;

    5. 安徽省高等学校省级自然科学研究重点项目“一种新型细菌漆酶全铜活性形式的样品制备方法和结构解析”,KJ2014A008,2015/01-2016/12;

    6. 安徽大学人才引进启动基金,2014/01-2018/12;

    已发表文章(*通讯作者,#第一作者):

    1. Yanhong Liu, Jigang Yu., Fudong Li, Hui Peng, Xuecheng Zhang, Yazhong Xiao, and Chao He*, Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13, Scientific reports, 2017, 7: 44067.

    2. Chao He#, Jing Li#, Wei Li, Yi Xue, Zeming Fang, Wei Fang, Xuecheng Zhang, Xiaotang Wang, Yazhong Xiao*, Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation, Journal of structural biology, 2016, 196: 426-436.

    3. Chao He*, Xianyu Huang, Yanhong Liu, Fudong Li, Yang Yang, Hongru Tao, Chuanchun Han, Chen Zhao, Yazhong Xiao, Yunyu Shi, Structural insights on mouse L-threonine dehydrogenase: A regulatory role of Arg180 in catalysis, Journal of structural biology, 2015, 192: 510-518.

    4. Chao He#, Fudong Li#, Jiahai Zhang, Jihui Wu*, Yunyu Shi*, The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition, The Journal of biological chemistry, 2013, 288: 4692-4703.

    5. Chao He, Sreerekha S. Francesca Taglini, Fudong Li, Ke Ruan, Jiahai Zhang, Jihui Wu, Yunyu Shi*, Elizabeth H. Bayne*, Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification, Proceedings of the National Academy of Sciences of the United States of America, 2013, 110: E1879-1888.

    6. Changlin Xie, Chao He, Yiyang Jiang, Hailong Yu,Lin Cheng, Gilbert Nshogoza, Moududee Sayed Ala, Changlin Tian, Jihui Wu, Yunyu Shi* andFudong LibStructural insights into the recognition of phosphorylated Hop1 by Mek1, Acta Crystallographica Section D-Structural Biology, 2018, 74: 1027-1038

    7. Yaqing Zhao#, Guang Zhang#, Chao He, Yide Mei, Yunyu Shi*, Fudong Li*, The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA, Cell research, 2018, 28: 130-134

    8. Wei Li#, Han Fan#, Chao He, Xuecheng Zhang, Xiaotang Wang, Jing Yuan, Zemin Fang, Wei Fang*, Yazhong Xiao*, PspAG97A: A Halophilic alpha-Glucoside Hydrolase with Wide Substrate Specificity from Glycoside Hydrolase Family 97. Journal of microbiology and biotechnology, 2016, 26: 1933-1942.