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王永中

来源:生命科学学院  发布时间:2017-11-08 访问次数:17176

  • 姓名:王永中

    邮箱:yongzhong00@126.com;yzwang@ahu.edu.cn

    职称:安徽大学生命科学学院,教授

    地址:安徽大学磬苑校区笃行北楼B401/B304

    邮政编码:230601

    个人简介:

      王永中,博士,教授,博士生导师,兼任教育部高校药学类教指委生物制药专业教指分委委员、安徽省食用菌技术协会理事长。1997年毕业于安徽大学微生物学专业,2003年毕业中国药物科大学微生物与生化药学专业,2007年毕业于复旦大学药剂学专业。2010-2015年先后在美国Auburn University药学院、University of Tennessee at Knoxville生物医学工程系、Ohio State University生物医学工程系与Wexner医学中心从事博士后及访问研究。近10年,主要在微生物组与微生态工程、多组学分析/微纳生物检测与微生态成像、益生菌/益生元与后生元、菌物科学与绿色功能食品等领域从事基础科学研究与应用技术转化。承担国家自然科学基金、省部级项目以及横向开发项目20余项,发表科研论文70余篇,申请/授权发明专利10余项。

    主要研究方向:

    (1)微生物组与微生态工程

    (2)多组学分析、微纳生物检测与微生态成像

    (3)益生菌、益生元与后生元

    (4)菌物科学与绿色功能食品

    主要科研论文(2016- ):

    [1] Sheng K., Yang J., Xu Y., Kong X., Wang J., Wang Y.* Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota. Food Funct., 2022,13, 1348-1359. https://doi.org/10.1039/D1FO03396D. (*corresponding author)

    [2] Si J., Dong X., Zhang G., Lu H., Tang K., Zhang L., Kong X., Sheng K., Wang J., Zha X., Wang Y.*. The fucose-specific lectin gene AOL_s00054g276 affects trap formation and nematocidal activity of the nematophagous fungus Arthrobotrys oligospora, FEMS Microbiology Letters, 2022, https://doi.org/0.1093/femsle/fnac013. (*corresponding author)

    [3] Wang J., An J., Zhang G., Wang R., Xu Y., Zhu F., Sheng K., Wang Y.*. Photosynthetic-bacteria-derived red emissive carbon dots with low toxicity for lysosomal imaging. Materials Letters 307 (2022) 131093. https://doi.org/10.1016/j.matlet.2021.131093. (*corresponding author)

    [4] Peng H., Dong X., Lu H., Kong X., Zha X., Wang Y.* A putative F-box-domain encoding gene AOL_s00076g207 regulates the development and pathogenicity of Arthrobotrys oligospora. Journal of Basic Microbiology, 2022; 62(1):74-81. https://doi.org/10.1002/jobm.202100388. (*corresponding author, cover paper)

    [5] Sheng K., Xu Y., Kong X., Wang J., Zha X., and Wang Y.*. Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation. Journal of Agricultural and Food Chemistry, 2021, 69(49): 14810–14823, https://doi.org/10.1021/acs.jafc.1c03375. (*corresponding author, cover paper)

    [6] Dong X., Si J., Zhang G., Shen Z., Zhang L., Sheng K., Wang J., Kong X., Zha X., and Wang Y.* The role of Jacalin-related lectin gene AOL_s00083g511 in the development and pathogenicity of the nematophagous fungus Arthrobotrys oligospora. Journal of Microbiology (2021) 59(8): 736–745. https://doi.org/10.1007/s12275-021-1029-4(*corresponding author)

    [7] Sheng K., Zhang G., Kong X., Wang J., Mu W., Wang Y.* Encapsulation and characterisation of grape seedproanthocyanidin extract using sodium alginate and different cellulose derivatives. International Journal of Food Science and Technology 2021, 56, 6420–6430. https://doi.org/10.1111/ijfs.15299. (*corresponding author)

    [8] Zuo K., Tang K., Liang Y., Xu Y., Sheng K., Kong X., Wang J., Zhu F., Zha X., Wang Y.*, Purification and antioxidant and anti-Inflammatory activity of extracellular polysaccharopeptide from sanghuang mushroom, Sanghuangporus lonicericola, Journal of the Science of Food and Agriculture, 2021; 101: 1009–1020, https://doi.org/10.1002/jsfa.10709. (*corresponding author)

    [9] Sheng K., Zhang G., Sun M., He S., Kong X., Wang J., Zhu F., Zha X., Wang Y.*, Grape seed proanthocyanidin extract ameliorates dextran sulfate sodium-induced colitis through intestinal barrier improvement, oxidative stress reduction, and inflammatory cytokines and gut microbiota modulation, Food & Function, 11 (2020) 7817-7829. https://doi.org/10.1039/D0FO01418D. (*corresponding author)

    [10] Sheng K., He S., Sun M., Zhang G., Kong X., Wang J., Wang Y*. Synbiotic supplementation containing Bifidobacterium infantis and xylooligosaccharide alleviates dextran sulfate sodium-induced ulcerative colitis, Food & Function, 2020, 11: 3964 - 3974. https://doi.org/10.1039/d0fo00518e. (*corresponding author)

    [11] Hou X., Shen Z., Li N., Kong X., Sheng K., Wang J., Wang Y*. A novel fungal beta-propeller phytase from nematophagous Arthrobotrys oligospora: characterization and potential application in phosphorus and mineral release for feed processing, Microbial cell factories 2020, 19: 84. https://doi.org/10.1186/s12934-020-01346-9. (*corresponding author)

    [12] Tian D., Zhang L., Zhang S., Kong X., Sheng K., Wang J., Zhang M., Wang Y.* Heterologous expression and molecular binding properties of AofleA, a fucose-specific lectin from nematophagous fungus Arthrobotrys oligospora, Int J Biol Macromol, 2020, 149: 1213-1221.https://doi.org/10.1016/j.ijbiomac.2020.02.039. (*corresponding author)

    [13] Li M., Wang J., Xu W., Wang Y., Zhang M., Wang M. Crystal structure of Akkermansia muciniphila peroxiredoxin reveals a novel regulatory mechanism of typical 2-Cys Prxs by a distinct loop, FEBS Letters, 2020, 594: 1550-1563.https://doi.org/10.1002/1873-3468.13753.

    [14] Xu W., Yang W., Wang Y., Wang M., Zhang M. Structural and biochemical analyses of β-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila involved in mucin degradation, Biochem Biophys Res Commun. 2020, 529(4):876-881. https://doi.org/10.1016/j.bbrc.2020.06.116.

    [15] Liu M., Cheng X., Wang J., Tian D., Tang K., Xu T., Zhang M., Wang Y., Wang M. Structural insights into the fungi-nematodes interaction mediated by fucose-specific lectin AofleA from Arthrobotrys oligospora, Int J Biol Macromol. 2020, 164:783-793. https://doi.org/10.1016/j.ijbiomac.2020.07.173.

    [16] Zuo Y.M., Yan X., Xue J., Guo L.Y., Fang W.W., Sun T.C., Li M., Zha Z., Yu Q., Wang Y., Zhang M., Lu Y., Cao B., He T, Enzyme-Responsive Ag Nanoparticle Assemblies in Targeting Antibacterial against Methicillin-Resistant Staphylococcus Aureus, ACS applied materials & interfaces, 2020, 12: 4333-4342.https://doi.org/10.1021/acsami.9b22001.

    [17] Chen X., Li M., Wang Y., Tang R., Zhang M. Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a beta-N-acetylhexosaminidase in Akkermansia muciniphila, Biochemical and biophysical research communications, 2019, 517: 29-35. https://doi.org/10.1016/j.bbrc.2019.06.150.

    [18] Chen X., Wang J., Liu M., Yang W., Wang Y., Tang R., Zhang M. Crystallographic evidence for substrate-assisted catalysis of beta-N-acetylhexosaminidas from Akkermansia muciniphila, Biochemical and biophysical research communications, 2019, 511: 833-839.https://doi.org/10.1016/j.bbrc.2019.02.074.

    [19] Wang Y, Yu L, Kong X, Sun L. Application of nanodiagnostics inpoint-of-care tests for infectious diseases, International Journal of Nanomedicine, 2017, 12:4789-4803. https://doi.org/10.2147/IJN.S137338.

    [20] Hu X, Liu L, Chen D, Wang Y, Zhang J, Shao L, Co-expression of the recombined alcoholde hydrogenase and glucose dehydrogenase and cross-linked enzyme aggregates stabilization, Bioresource Technology, 2017, 224:531-535. https://doi.org/10.1016/j.biortech.2016.10.076.

    [21] Wang Y*, Fan Z, Shao L, Kong X, Hou X, Tian D, Sun Y, Xiao Y,Yu L. Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications, International Journal of Nanomedicine,2016, 11:3287-3303.https://doi.org/10.2147/IJN.S107194. (*corresponding author)

    [22] Gan X, Zhang X, Cheng Z, Chen L, Ding X, DuJ, Cai Y, Luo Q, Shen J, Wang Y*, Yu L*. Toxoplasma gondii inhibits differentiation of C17.2 neural stem cells through Wnt/β-catenin signaling pathway, Biochemical and Biophysical Research Communications, 2016, 473:187-193.https://doi.org/10.1016/j.bbrc.2016.03.076.  (*corresponding author)

    [23] Fan Z, Sun L, Huang Y, Wang Y, Zhang M. Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release, Nature Nanotechnology, 2016, 11:388-394.https://doi.org/10.1038/nnano.2015.312.

    [24] Sun L., Huang Y., Bian Z., Petrosino J., Fan Z., Wang Y., Park K., Yue T., Schmidt M.,Galster S., Ma J., Zhu H., Zhang M. Sundew-Inspired Adhesive Hydrogels Combined with Adipose- Derived Stem Cells for Wound Healing, ACS Applied Materials & Interfaces, 2016, 8 (3):2423-2434.https://doi.org/10.1021/acsami.5b11811.