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刘琳

来源:生命科学学院  发布时间:2017-03-20 访问次数:19685

    • 姓名:刘琳

      邮箱:liulin@ahu.edu.cn

      职称:教授

      地址:安徽省合肥市经开区九龙路111号 

      邮政编码:230601


    个人简介:

    刘琳,博士生导师,现任中国植物生理与植物分子生物学学会(第十二届)光合作用专业委员会委员。2006年在中国科学技术大学获得博士学位,2006-2010年在美国糖尿病与消化及肾脏疾病研究所从事博士后研究,2010-2021年分别获中科院、安徽省、教育部等多项人才计划资助。主要运用生物大分子晶体学的方法研究生物色素代谢的分子机理,作为通讯作者发表论文二十余篇,培养研究生三十余名。主讲本科生《生物化学》、《遗传学》以及研究生《结构生物学实验原理》等课程,2021年被评为安徽大学师德标兵。


    主要研究方向:

    1)蛋白质晶体学

    2)光生物化学

    3)生物无机化学


    主要科研论文(2020-):

    [1] Gao YS, Wang YL, Wang X, Liu L* (2020) Hexameric structure of the ATPase motor subunit of magnesium chelatase in chlorophyll biosynthesis. Protein Sci 29, 1040-1046

    [2] Dong CS, Zhang WL, Wang Q, Li YS, Wang X, Zhang M, Liu L* (2020) Crystal structures of cyanobacterial light-dependent protochlorophyllide oxidoreductase. Proc Natl Acad Sci USA 117, 8455-8461

    [3] Niu G, Guo Q, Wang J, Zhao S, He Y*, Liu L* (2020) Structural basis for plant lutein biosynthesis from alpha-carotene. Proc Natl Acad Sci USA 117, 14150-14157

    [4] Wang J, Guo Q, Li X, Wang X, Liu L* (2020) The Arabidopsis locus AT3G03890 encodes a dimeric beta-barrel protein implicated in heme degradation. Biochem J 477, 4785-4796

    [5] Zhang JH, Yuan H, Wang X, Dai HE, Zhang M, Liu L* (2021) Crystal structure of the large subunit of cobaltochelatase from Mycobacterium tuberculosis. Proteins 89, 462-467

    [6] Hu JH, Chang JW, Xu T, Wang J, Wang X, Lin R, Duanmu D, Liu L*. (2021) Structural basis of bilin binding by the chlorophyll biosynthesis regulator GUN4. Protein Sci 30, 2083-2091

    [7] Yang J, Gao M, Wang J, He C, Wang X, Liu L* (2022) Structural basis of copper binding by a dimeric periplasmic protein forming a six-helical bundle. J Inorg Biochem 229, 111728

    [8] Pan W, Zhou YL, Wang J, Dai HE, Wang X, Liu L* (2022) Structural and functional analysis of nonheme iron enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans. Front Mol Biosci 9, 844453

    [9] Zhang C, Zhao S, Li YS, He C, Wang X, Liu L* (2022) Crystal structures of Arabidopsis thaliana GDP-D-mannose pyrophosphorylase VITAMIN C DEFECTIVE 1. Front Plant Sci 13, 899738

    [10] Wang J, Niu G, Guo Q, Liu L* (2022) Production and structural characterization of the cytochrome P450 enzymes in carotene ring hydroxylation. Methods Enzymol 671, 223-241