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蒋善群

来源:生命科学学院  发布时间:2017-02-15 访问次数:12643




  • 姓名:蒋善群                                  

    邮箱:shanqunjiang2014@163.com

    职称:教授

    地址:安徽大学磬苑校区笃行北楼B306

    邮政编码: 230601

    蒋善群,博士,教授,博士生导师,安徽大学生物统计系主任,安徽省高校学科(专业)拔尖人才,安徽省学科带头人后备人选,合肥市十大优秀青年,中国药理学会会员,中国药理精准分析委员会青年委员。

    教育经历:

     2013 ~ 2014美国弗吉尼亚大学医学院,访问学者

     2003 ~ 2005美国哈佛大学公共卫生学院,研究学者

     1999 ~ 2005中国科学技术大学生命科学学院硕博连读,博士

     1994 ~ 1998安徽大学生物系生物化学专业,学士

    工作经历:

    2018 ~现在 安徽大学生命科学学院 教授

    2017 ~现在 安徽大学生物统计学系 主任

     2007 ~ 2018安徽大学生命科学学院 副教授

     2005 ~ 2007安徽医科大学生物医学研究所 副研究员

     2005 ~ 2007安徽医科大学生物医学研究所分子医学中心 主任

    研究方向及科研成果:

    主要研究方向:心脑血管疾病精准医学、药物基因组学、遗传流行病学及分子医学遗传学。

    截至2018年,已在多种国际国内核心专业先后刊印或接受科学论著50余篇,包括《Clinical Pharmacology & Therapeutics》、《Journal of Hypertension》、《Journal of Lipid Research》、《American Journal of Hypertension》等,其中属SCI期刊论文35篇。长期担任《Cardiovascular therapy》、《Clin Appl Thromb Hemost》等专业杂志担任审稿人。多次应邀在国际国内心血管学术大会上作主题演讲。已承担国家自然科学基金4项,参与美国NIH资助项目1项,主持省部级多项。

    承担科研项目及人才计划项目:

    (1)主持国家自然科学基金:调脂药辛伐他汀有效性与安全性的药物遗传学研究

    (2)主持国家自然科学基金:脑卒中预防的药物基因组学研究-前瞻性巢式病例-对照研究设计

    (3)主持国家自然科学基金:苯那普利个体药物反应差异的易感基因定位研究

    (4)参与国家自然科学基金项目主任基金:氨氯地平以及与alpha1受体拮抗剂不同组方对下尿路综合征的治疗作用及机制研究

    (5)参与美国NIH项目:哮喘疾病的基因精细定位研究

    (6)安徽省学科带头人后备人选人才项目

    (7)安徽省高校学科(专业)拔尖人才学术资助重点项目

    已发表的主要科学论文:(第一或通讯作者)

    1. Tao F, Weinstock J, Venners SA, Cheng J, Hsu YH, Zou Y, Pan F, Jiang S*, Zha X, Xu X. Associations of the ABCA1 and LPL Gene Polymorphisms With Lipid Levels in a Hyperlipidemic Population. Clin Appl Thromb Hemost.2018;24(5):771-779.

    2. Cheng J, Tao F, Liu Y, Venners SA, Hsu YH, Jiang S*, Weinstock J, Wang B, Tang G, Xu X. Associations of methylenetetrahydrofolate reductase C677T genotype with blood pressure levels in Chinese population with essential hypertension. Clin Exp Hypertens. 2018;40(3):207-212.

    3. Liu Y, Kong X, Wang W, Fan F, Zhang Y, Zhao M, Wang Y, Wang Y, Wang Y, Qin X, Tang G, Wang B, Xu X, Hou FF, Gao W, Sun N, Li J, Venners SA, Jiang S*, Huo Y. Association of Peripheral Differential Leukocyte Counts with Dyslipidemia Risk in Chinese Patients with Hypertension: Insight from the CSPPT. J Lipid Res. 2017;58(1):256-266.

    4. Jiang S*, Venners SA, Li K, Hsu YH, Weinstock J, Zou Y, Pan F, Xu X. Effect modification by region in the associations of LEP G2548A and LEPR Q223R polymorphisms with statin-induced CK elevation. Oncotarget. 2017;8(64):107565-107576.

    5. Jiang S, Li J, Zhang Y, Venners SA, Tang G, Wang Y, Li Z, Xu X, Wang B, Huo Y. Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study. Int J Neurosci.  2017;127(3):253-260.

    6. Jiang S*, Venners SA, Hsu YH, Weinstock J, Wang B, Xing H, Wang X, Xu X.  Interactive Effect of the KCNJ11 Ile337Val Polymorphism and Cigarette Smoking on the Antihypertensive Response to Irbesartan in Chinese Hypertensive Patients. Am J Hypertens. 2016; 29(5):553-9.

    7. Li K, Liu Y, Venners SA, Hsu YH, Jiang S*, Weinstock J, Sun Y, Wang B, Xu X. Effects of LEP G2548A and LEPR Q223R Polymorphisms on Serum Lipids and Response to Simvastatin Treatment in Chinese Patients With Primary Hyperlipidemia. Clin Appl Thromb Hemost. 2017;23(4):336-344.

    8. Liu Y, Li K, Venners SA, Hsu YH, Jiang S*, Weinstock J, Wang B, Tang G, Xu X.  Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension. Clin Appl Thromb Hemost. 2017;23(3):287-293.

    9. Jiang S*, Pan M, Wu S, Venners SA, Zhong G, Hsu Y, Weinstock J, Xu X. Elevation in Total Homocysteine Levels in Chinese Patients With Essential Hypertension Treated With Antihypertensive Benazepril. Clin Appl Thromb Hemost. 2016; 22(2):191-8.

    10. Jiang S*, Zhao R, Pan M, Venners SA, Zhong G, Hsu YH. Associations of MTHFR and MTRR Polymorphisms With Serum Lipid Levels in Chinese Hypertensive Patients. Clin Appl Thromb Hemost.  2014;20(4):400-10.

    11.  Wang Y, Xu X, Huo Y, Liu D, Cui Y, Liu Z, Zhao Z, Xu X, Liu L, Li X, Jiang S*. Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension. Clin Appl Thromb Hemost. 2015;21(7):661-6.

    12. Jiang S*, Chen Q, Venners SA, Zhong G, Hsu YH, Xing H, Wang X, Xu X. Effect of simvastatin on plasma homocysteine levels and its modification by MTHFR C677T polymorphism in Chinese patients with primary hyperlipidemia. Cardiovasc Ther. 2013;31(4):e27-33.

    13. Jiang S*, Hsu YH, Venners SA, Zhang Y, Xing H, Wang X, Xu X. Interactive Effect of Angiotensin II Type 1 Receptor (AGT1R) Polymorphisms and Plasma Irbesartan Concentration on Antihypertensive Therapeutic Responses to Irbesartan. J Hypertens. 2011; 29(5): 890-5.

    14. Jiang S*, Hsu YH, Venners SA, Zhang Y, Xing H, Wang X, Xu X. Effects of protein coding polymorphisms in the kallikrein 1 gene on baseline blood pressure and antihypertensive response to irbesartan in Chinese hypertensive patients. J Hum Hypertens. 2011; 25(5): 327-33.

    15. Jiang S*, Yu Y, Venners SA, Zhang Y, Xing H, Wang X, Xu X. Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients. J Hum Hypertens. 2011; 25(3):172-7.

    16.  Chen QR, Jiang SQ*, Xu XP. Polymorphism of genes encoding homocysteine metabolism-related enzymes and risk for cardio-cerebrovascular disease. Zhonghua Xin Xue Guan Bing Za Zhi. 2012;40(9):801-3.

    17. Jiang SQ*, Xu XP. Pharmacogenomics of renin angiotensin system inhibitors. Zhonghua Xin Xue Guan Bing Za Zhi. 2010;38(1):90-3.

    18. Jiang S*, Mao G, Zhang S, Hong X, Tang G, Li Z, Liu X, Zhang Y, Wang B, Xu X, Wang X. Individual and joint association of alpha1A-adrenergic receptor Arg347Cys polymorphism and plasma irbesartan concentration with blood pressure therapeutic response in Chinese hypertensive subjects. Clin Pharmacol Ther. 2005;78(3):239-48.

    19. Jiang S, Hsu YH, Niu T, Xu X, Xing H, Chen C, Wang X, Zhang Y, Peng S, Xu X. A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study. Clin Exp Hypertens. 2005;27(6):509-21.

    20. Jiang S, Hsu YH, Xu X, Xing H, Chen C, Niu T, Zhang Y, Peng S, Xu X. The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor. Thromb Res. 2004;113(6):361-9.

    非第一或通讯作者论文:

    1. Wang M, Yao Y, Jiang S, Tao F, Tang R, Sun J. How to Control Asthma with Personalized Management: Where Do We Stand Now? Curr Drug Metab. 2018 Jan 28. doi: 10.2174/1389200219666180129111810.

    2. Huang X, Qin X, Yang W, Liu L, Jiang C, Zhang X, Jiang S, Bao H, Su H, Li P, He M, Song Y, Zhao M, Yin D, Wang Y, Zhang Y, Li J, Yang R, Wu Y, Hong K, Wu Q, Chen Y, Sun N, Li X, Tang G, Wang B, Cai Y, Hou FF, Huo Y, Wang H, Wang X, Cheng X. MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment. Arterioscler Thromb Vasc Biol. 2018;38(3):679-685.

    3. Han R, Yang X, Chen M, Zhang X, Yuan Y, Hu X, Wang M, Liu R, Ma Y, Yang J, Xu S, Shuai Z, Jiang S, Pan F. Changes and clinical significance of CD8+CD122+ T cells in the peripheral blood of patients with ankylosing spondylitis. Clin Rheumatol. 2018 Mar;37(3):639-646. 

    4. Yang J, Zhang X, Ma Y, Wu M, Hu X, Han R, Yuan Y, Wang M, Chen M, Jiang S, Tong J, Xu S, Xu J, Shuai Z, Zou Y, Pan F. Serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis: A systematic review and meta-analysis. Int Immunopharmacol. 2017;52:310-317. 

    5. Chen G, Jiang S, Mao G, Zhang S, Hong X, Tang G, Li Z, Liu X, Zhang Y, Xing H, Wang B, Yu Y, Xu X. CYP2C9 Ile359Leu Polymorphism, Plasma Irbesartan Concentration and Acute Blood Pressure Reductions in Response to Irbesartan Treatment in Chinese Hypertensives. Methods Find Exp Clin Pharmacol. 2006;28(1):19-24.

    6. Zhou H, Hong X, Jiang S, Dong H, Xu X, Xu X. Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population. BMC Med Genet. 2009;10:123.

    7. Feng Y, Hong X, Wang L, Jiang S, Chen C, Wang B, Yang J, Fang Z, Zang T, Xu X, Xu X. G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population. J Allergy Clin Immunol. 2006;117(3):612-7.  

    8. Xiping Xu, Zhian Fang, Shanqun Jiang, Jianhua Yang, Shanchun Zhang, Guangyun Mao, Houxun Xing, Ping Liu, Yan Wang, Tonghua Zang, Mengde Wang, Yu Wang, Chengxiang Dai, Kerong Zhang. Useages of MTHFR gene polymorphisms in predicting homocysteine level, disease risk, and treatment effects and related methods and kit. Pub. No.: US 2007/0134709 A1, Pub. Date: Jun. 14, 2007.

    9. Liu H, Zhang S, Jiang S, Mao G, Hong X, Yu Y, Zhang Y, Tang G, Xing H, Xu X. Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives. Methods Find Exp Clin Pharmacol. 2008;30(4):307-12.  

    10. Mao G, Hong X, Xing H, Liu P, Liu H, Yu Y, Zhang S, Jiang S, Wang X, Xu X. Efficacy of Folic Acid and Enalapril Combined Therapy on Reduction of Blood Pressure and Plasma Glucose: A Multi-center, Randomized, Double Blind, Parallel Controlled, Clinical Trial. Nutrition. 2008 Jul 23  

    11. Hong X, Hsu YH, Terwedow H, Tang G, Liu X, Jiang S, Xu X, Xu X. Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women. Bone. 2007 Mar;40(3):737-42.  

    12. Zhang S, Liu P, Jiang S, Hong X, Xing H, Xu X. Association of cigarette smoking with steady-state plasma concentration of irbesartan in male Chinese with hypertension. Methods Find Exp Clin Pharmacol. 2005;27(3):173-8.

    13. Hong X, Zhang S, Mao G, Jiang S, Zhang Y, Yu Y, Tang G, Xing H, Xu X. CYP2C9*3 allelic variant is associated with metabolism of irbesartan in Chinese population. Eur J Clin Pharmacol. 2005;61(9):627-34.  

    14. Zhang S, Mao G, Zhang Y, Tang G, Wen Y, Hong X, Jiang S, Yu Y, Xu X. Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in Rural Chinese patients with essential hypertension. Clin Ther. 2005;27(11):1774-84.  

    15. Wang L, Feng Y, Zhang Y, Zhou H, Jiang S, Niu T, Wei LJ, Xu X, Xu X, Wang X. Prolylcarboxypeptidase Gene, Chronic Hypertension, and Risk of Preeclampsia. American Journal of Obstetrics and Gynecology. 2006 May 6;